But why would you want to take a pills like this otc without seeing a doctor? Diflucan is quite a powerful drug with many potential side effects. If you go to many databases on line, you can read about all the nasty side effects from Fluconazole or Diflucan. It has some powerful effects on the liver. So my advice to you if you must take this pills is to take it in a very short period of time and certainly don’t repeatedly take this drug.